The Bamboo does have 4 buttons that can be programmed (the Intuos has way more:). I use mine for things like "shift" and "control" since those are so often used as modifiers in PS. The right click of the pen can be programed to start up things or perform Photoshop (or PSP) commands. I have it set to open The Font Thing for ease of font choosing, to save, open new document, undo (which will KEEP undoing like in the history section of PS, not just one time use like control/Z), new layer, brush tool, move tool, delete, delete selection. This all keeps hands free to not have to come up to the keyboard as often. I even programed it to open the Word document I keep my layout artist assignments in, and the Excel document in which I keep track of my SG products. I love having my most-used things handy with a simple click!
I have two versions of the bamboo and the intuos 4. You don't actually see on the tablet what you are doing. However, with the centique you do it on the screen. I've seen it demonstrated and it is amazing! way beyond what i need though, can't justify the expense. Even the intuos is probably more than I need. I imagine it would work fine with any drawing program. I know my son who uses autoCAD a lot has used it. If you get one, the ones with buttons are very useful because you can program the buttons for the commands you use the most. I use them for "save as" , "file info", "save" , etc. The basic bamboo doesn't have that capability. I have the small size for my bamboo tablets, my take everywhere I take my laptop, ones. I have the medium size intuos which live on the desk with the big iMac. I use it for more detailed work. I love using my tablets for gaming, so much faster moves. You can also program the buttons on the pen and in photoshop, set a preference so the pen pressure is sensed. That is handy for brushwork. The lighter the pen pressure, the smaller the brush, heavier pressure the bigger the brush. I will never go back to a mouse again. Some of the tablets have a special mouse that you can use on the tablet instead of the pen, but I've just thrown those in a drawer and never used them. I picked up the pen and right away knew I was on to something I was going to love, but other people don't adjust to it as easily and some have them and they sit idle. If you could try one out before you buy it would be great, but I will tell you, I absolutely love, love, love mine.